| （1.华东师范大学 体育与健康学院，上海 200241；2.华东师范大学 青少年健康评价与运动干预教育部重点实验室，上海 200241） 摘 要：对运动与骨内分泌系统研究进行综合评述。骨作为新型的内分泌器官，具有内分泌功能。目前研究的重点主要是：骨钙素(OCN)和成纤维细胞生长因子23(FGF23)。其中OCN经过羧化后形成uOCN，再作用于脂肪细胞和胰岛，以此调节瘦素、脂联素、胰岛素的分泌，最终作用于骨，形成反馈性回路，进而调控能量代谢。而运动可能通过调节骨内分泌系统进而影响骨代谢，且不同方式运动对骨内分泌的调节不同，尤其是内分泌本质上是寻求内环境的稳定性，短时间或一次性运动对机体意义不大；当进行长期运动时，在调节骨结构的同时可显著影响相应因子，进而稳定骨内分泌系统。这为运动改善骨及其机体代谢的分子生物学机制提供了新的思路。 |
XU Shuai1，2，LI Shi-chang1，2，FANG Xing1，2
| （1.School of Physical Education and Health，East China Normal University，Shanghai 200241，China；2. Key Lab of “Evaluating and Sports Intervening to Adolescent’s Health”of Ministry of Education，East China Normal University，Shanghai 200241，China) Abstract: The authors carried out a comprehensive review of exercise and bone endocrine system researches. As a new endocrine organ, bone has endocrine functions. Currently, research priorities are mainly osteocalcin (OCN) and fibroblast growth factor 23(FGF23), in which OCN is carboxylated into uncarboxylated osteocalcin (uOCN), then works on fat cells and islet, thus regulates the secretion of leptin, adiponectin and insulin, and ultimately, works on the bone, forms a feedback circuit, and then regulates energy metabolism. While exercise may affect bone metabo-lism by regulating the bone endocrine system, and different ways of exercise has a different effect on bone endo-crine regulation, especially, the essence of endocrine is to seek for internal environment stability, short-time or one-time exercise is insignificant for the body; long-term exercise can significantly affect corresponding factors while regulating the bone structure, thus stabilize the bone endocrine system. This provides a new idea for exercise improving the molecular biological mechanism of bone and body metabolism. |
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