| （1.华东师范大学 青少年健康评价与运动干预教育部重点实验室，上海 200241；2.华东师范大学体育与健康学院，上海 200241；3.郑州大学 西亚斯国际学院 体育学院，河南 新郑 451100；4.安庆师范学院 体育学院，安徽 安庆 246011） 摘 要：综述评价骨免疫学的主要任务是研究生理和病理情况下免疫系统和骨骼系统在细胞水平和分子水平的相互作用及机制的研究进展。该过程极其复杂，不仅包含T细胞、B细胞对骨代谢的调控，还包含骨免疫相关因子，如RANKL、TNF-α、IFN-γ等对骨代谢的影响。运动可能通过调节骨免疫系统进而影响骨代谢，且不同运动强度之间存在一定差异，中小强度运动可能促进淋巴细胞增殖，上调IFN-γ等表达，降解TRAF 6，进一步抑制RANKL信号，抑制OC形成；大强度运动则能抑制免疫机能，上调TNF-α、IL等因子表达，直接或间接激活RANKL信号通路，促进骨吸收。这也为丰富运动调控骨代谢的分子生物学机制研究提供了新思路。 |
WANG Yan-jie1，2，LI Shi-chang1，2，YANG Nian-en3
| （1.Key Lab of “Evaluating and Sports Intervening to Adolescent’s Health”of Ministry of Education，East China Normal University，Shanghai 200241，China；2.School of Physical Education and Health，East China Normal University，Shanghai 200241，China；3. School of Physical Education，SIAS International University，Xinzheng 451100，China； 4.School of Physical Education，Anqing Normal University，Anqing 246011，China) Abstract: The main task of osteoimmunology is to study the mechanism of interaction between the immune system and the skeletal system at cell and molecule levels, under physiological and pathological conditions. This process is extremely complicated, comprising not only bone metabolism regulation made by T cells and B cells, but also the effects of bone immune related factors such as RANKL, TNF-α and IFN-γ etc on bone metabolism. Exercise may affect bone metabolism by regulating the bone immune system, and there are certain differences between different intensities. Medium and low intensity exercise can promote lymphocyte proliferation, up regulate the expression of IFN-γ etc, degrade TRAF 6, further restrain RANKL signal and OC formation; while high intensity exercise can re-strain immune functions, up regulate the expression of factors such as TNF-α and IL, directly or indirectly activate RANKL signal pathway, and promote bone absorption. This study also provides a new idea for enriching the study of the molecular biological mechanism of exercise regulating bone metabolism. |
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