| （1.华南师范大学 体育科学学院，广东 广州 510631；2.广州后勤医院 皮肤科，广东 广州 510052） 摘 要：为探讨不同强度的运动结合药物治疗对白癜风患者皮损区面积，以及血浆和组织液内皮素-1(ET-1)含量的影响，选取白癜风患者45例随机分成3组：安静对照组(单纯药物治疗)、中等强度运动组(中等强度运动+药物治疗)、大强度运动组(大强度运动+药物治疗)，每组15例。中等强度运动组采取跑步运动，运动强度维持在心率120~140 次/min，每次1 h；大强度运动组采取跳绳运动，心率为160~170 次/min，1 d累计1 h。每周运动5 d，共进行16周的运动。16周运动干预前后，采取患者血液及组织液，应用放射免疫法测定ET-1质量浓度。通过对血浆微量元素的检测判断铜离子的变化；通过肢端血管微循环检测血管侧枝及管径的变化。结果发现：1)运动使血浆、组织液ET-1质量浓度明显增加，其中以大强度运动组增加最为显著；2)16周运动前后，安静对照组与两个运动强度组的血铜离子均增加，安静对照组增加显著，而运动组只是出现微量增加；3)长期有规律的运动增加了患者血管侧枝及管径，促进了血液循环；4)实验后3组患者皮损区缩小与实验前有显著差异，实验后3组之间皮损区缩小面积差异没有显著性，但运动组比安静对照组缩小面积大。结果说明，运动可作为白癜风患者的辅助治疗手段，其中以大强度运动效果较佳。 |
LIU Fu-quan1，WANG Song-tao1，LIU Zhong-hai2
| （1.School of Physical Education，South China Normal University，Guangzhou 510006，China；2.Department of Dermatology，Guangzhou Logistics Hospital，Guangzhou 510052，China) Abstract: In order to probe into the effects of exercising of different intensities combined with medicament treat-ment on the area of skin lesion areas and ET-1 in plasma and tissue fluid of vitiligo patients, the authors selected 45 vitiligo patients and divided them randomly into 3 groups: a calm control (pure medicament) group, a medium in-tensity exercising (medium intensity exercising + medicament treatment) group, and a high intensity exercising (high intensity exercising + medicament treatment) group (each group included 15 patients), let the patients in the medium intensity exercising group run for 1 hour per time, at an exercising intensity that maintained the heart rate at 120-140 beats/min, let the patients in the high intensity exercising group do a rope skipping exercise for accumula-tively 1 hour per day and maintain their average heat rate at 160-170 beats/min during exercising, let the patients in the two exercising groups exercise for totally 16 weeks, 5 days per week, drew the patients’ blood and tissue fluid before and after 16-week exercising intervention, measured ET-1 mass concentration by applying radioimmunoas-say, determined the changing of copper ions by measuring trace elements in plasma, checked the changing of collat-eral blood vessels and vessel diameters by means of extremity vascular microcirculation, and revealed the following findings: 1)exercising increased ET-1 mass concentration in plasma and tissue fluid significantly, the patients in the high intensity exercising group had the most significant increase; 2)before and after 16-week exercising, the patients in calm control group and the two exercising groups had an increased number of serum copper ions, the patients in the calm control group had a significant increase, while the patients in the exercising groups had only a slight increase; 3)long term regular exercising increased the patients’ collateral blood vessels and vessel diameters, boosted blood cir-culation; 4)After the experiment, the shrinking of skin lesion areas of the patients in the three groups had a significant difference from that measured before the experiment, there was no significant difference in the shrunk area of skin le-sion areas between the patients in the three groups after the experiment, but the patients in the exercising groups had a larger shrunk area than the patients in the calm control group. The said findings indicated that exercising can be used as an auxiliary means for treating vitiligo patients, high intensity exercising therein produces a better effect. |
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