骨髓中IL-7、IL-7R及EBF表达与运动性免疫抑制

（1.山东体育学院基础理论系，山东济南 250102；2.华南师范大学体育科学学院，广东广州 510006）

摘      要：IL-7在早期B细胞的增殖中起到了关键的促进作用，EBF在淋巴系干细胞向B系细胞分化中起着决定性的系谱特异定型作用。IL-7、IL-7R通过维持EBF表达，参与了B细胞增殖转录因子网络的形成，这与早期B细胞分化调控密切相关。运动中GC的升高会加快早期发育中B细胞的凋亡，研究B细胞的发育及其调控机制对寻求更有效的运动免疫调理措施具有重要意义。
关  键  词：运动免疫学；骨髓；B淋巴细胞；白细胞介素7；白细胞介素7受体；早期B细胞因子；综述
中图分类号：G804.7    文献标识码：A    文章编号：1006-7116(2011)01-0139-06

Expression of IL-7、IL-7R and EBF in the bone marrow& exercise-induced immune suppression
GENG Qing-qing1，HAO Xuan-ming2

（1.Department of Basic Theory，Shandong Institute of Physical Education and Sports，Jinan 250102，China；2.School of Physical Education，South China Normal University，Guangzhou 510006，China）

Abstract: IL-7 is an important cytokine for B lymphocytes development and can promote B lymphocytes progeni-tors transition and. Expression of EBF is critical for the lineage specification at the early stage of B cell develop-ment. IL-7 and IL-7R are participants in the formation of the transcription factor network during B lymphopoiesis by maintaining the EBF expression level above a certain threshold. These are necessary for further transition of B cell progenitors. Elevated GC in exercise induces rapidly apoptosis in developing B lymphocytes. It is important and practical for athletes，immune modification to study the lymphocyte development and its regulation.
Key words: exercise immunology；bone marrow；B lymphocytes；IL-7；IL-7R；EBF；summary

分享: