| （1.广东海洋大学 体育与休闲学院，广东 湛江 524008；2.广州体育学院 省重点生化实验室，广东 广州 510075；3.信阳师范学院 体育学院，河南 信阳 464000） 摘 要：探讨间歇低氧运动对营养性肥胖SD大鼠摄食的影响并分析其可能机制，为间歇低氧减肥提供理论依据。为此，通过对雄性SD大鼠饲喂高脂饲料建立营养性肥胖模型，然后进行为期4周的间歇低氧运动(运动速度为20 m/min， (O2)前2周为15.4％，后2周为14.5％)。间歇低氧运动组进行4周间歇低氧运动刺激。结果发现：与常氧安静组相比，常氧运动组和间歇低氧运动组肥胖SD大鼠下丘脑瘦素和瘦素受体含量增加(常氧运动组P<0.05，间歇低氧运动组P<0.01)，大鼠的每日摄食量减少。与常氧运动组相比，间歇低氧运动组肥胖SD大鼠下丘脑瘦素和瘦素受体含量增加(瘦素P<0.05，瘦素受体P<0.01)。结果说明：1)间歇低氧运动抑制了肥胖大鼠的食欲，减少了摄食量，减缓了大鼠体重的增加，并且间歇低氧效果比单纯运动效果好；2)间歇低氧运动抑制大鼠食欲可能与大鼠下丘脑瘦素和瘦素受体含量增加，进而抑制神经肽Y有关。 |
CHEN Yu-wen1，LIN Wen-tao2，QIU Lie-feng3，WENG Xi-quan1
| （1.School of Sports and Leisure，Guangdong Ocean Univesity，Zhanjiang 524088，China；2.Provincial Key Laboratory of Biochemistry，Guangzhou Sport University，Guangzhou 510075，China；3.School of Physical Education，Xinyang Normal University，Xinyang 464000，China） Abstract: The authors probed into the effect of intermittent hypoxic exercising on the ingestion of nutritional obese SD rats, so as to provide a theoretical criterion for weight reduction through intermittent hypoxic exercising. Hence, the authors established a nutritional obesity model for feeding male SD rats with high fat feed, then let the rats in the intermittent hypoxic exercising group do a 4-week intermittent hypoxic exercise (exercising speed: 20 m/min, (O2): 15.4% in the first two weeks, 14.5% in the last two weeks), and revealed the following findings: as com-pared with the rats in the normoxic calm group, the contents of hypothalamus leptins and leptin receptors of obese SD rats in the normoxic exercising group and intermittent hypoxic exercising group increased (the rats in the nor-moxic exercising group: P<0.05, the rats in the intermittent hypoxic exercising group: P<0.01), and the daily inges-tion of the rats decreased; as compared with the rats in the normoxic exercising group, the contents of hypothalamus leptins and leptin receptors of obese SD rats in the intermittent hypoxic exercising group increased (leptins: P<0.05, leptin receptors: P<0.01). The findings indicated the followings: 1) intermittent hypoxic exercising restrained the appetite of obese rats, reduced their ingestion, and slowed down the increase of their weight; the effect of intermit-tent hypoxic exercising was better than the effect of simple exercising; 2) intermittent hypoxic exercising restraining the appetite of the rats may be related to the restraining of neuropeptide Y as a result of the increase of the contents of hypothalamus leptins and leptin receptors of the rats. |
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