运动对胰岛素抵抗骨骼肌AMPK/SIRT1/PGC-1α轴影响的研究述评

（1.暨南大学体育部，广东广州 510632；2.华南师范大学体育科学学院，广东广州 510006；3.暨南大学华侨医院，广东广州 510632）

摘      要：SIRT1(沉默信息调节因子2相关酶I)是依赖于辅酶NAD+的去乙酰化酶，不仅与衰老、凋亡、DNA修复有关，还与不同营养应激状态的细胞代谢转换相关。SIRT1和AMPK(腺苷酸活化蛋白激酶)是细胞内的能量感受器，通过磷酸化、去乙酰化调节着PGC-1α的活性。骨骼肌AMPK/SIRT1/PGC-1α轴的活性调控直接影响着其下游相关基因的表达，与胰岛素抵抗的发生与发展密切相关。
关  键  词：运动生物化学；胰岛素抵抗；骨骼肌；腺苷酸活化蛋白激酶；沉默信息调节因子2相关酶I；过氧化物酶体增殖物激活受体γ辅激活子1α；综述
中图分类号：G804.2    文献标识码：A    文章编号：1006-7116(2010)11-0106-05

Review of the research on the effects of exercising on insulin resisting the AMPK/SIRT1/PGC-1α axis in skeletal muscle
ZHAO Jun1，2，XU Xiao-yang2，FU Qiang3

（1.Department of Physical Education，Jinan University，Guangzhou 510630，China；2.School of Physical Education，South China Normal University，Guangzhou 510006，China；3.Huaqiao Hospital，Jinan University，Guangzhou 510630，China）

Abstract: Silent information regulation factor 2 related enzyme I (SIRT1) is a coenzyme NAD+ dependent deace-tylase, not only related to aging, dying and DNA repairing, but also correlative with cellular metabolic transforma-tion in different nutrition stress states. SIRT1 and AMPK are energy receptors in cells, regulating the activity of PGC-1α by means of phosphorylation and deacetylation. The regulation of the activity of the AMPK/SIRT1/PGC-1α axis directly affects the expression of its downstream genes related, being closely related to the occurrence and de-velopment of insulin resistance.
Key words: sports biochemistry；insulin resistance；skeletal muscle；AMPK；SIRT1；PGC-1α；summary

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