| （1.苏州大学 体育学院，江苏 苏州 215021；2.湛江教育学院 体育系，广东 湛江 524037；3.商丘师范学院 体育系，河南 商丘 476000） 摘 要：基质金属蛋白酶是降解肌腱细胞外基质蛋白的重要蛋白酶，在肌腱重塑中具有重要的作用。一些基质金属蛋白酶对保持肌腱的健康是必需的，而另一些可能会导致肌腱的损伤。目前研究表明机械负载、炎性因子影响腱细胞中基质金属蛋白的表达和活性，共同作用于腱细胞时具有协同或抑制效应。适当运动可使肌腱发生重塑，改善其力学性能、生化组成及结构。 |
ZHANG Lin1，SONG Bing2，LI Min3
| (1.School of Physical Education，Soochow University，Suzhou 215021，China； 2.Department of Physical Education，Zhanjiang Educational College，Zhanjiang 524037，China；3. Department of Physical Education，Shangqiu Normal College，Shangqiu 476000，China) Abstract: Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix compo-nents, and these are thought to play a major role in the degradation of matrix during tendon remodeling. Some met-alloproteinase enzymes are required for the health of the tendon, and others may be damaging, leading to degenera-tion of the tissue. Now researches indicated mechanical loading and cytokines can regulate MMPs expression and activity, and there is a synergetic or inhibitory effect between them. Exercise leads to tendon remodeling, changing its biomechanical, biochemical and structural properties. |
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