| （咸宁学院 1.体育系； 2.医学院解剖教研室，湖北 咸宁437100） 摘要：为了检验长期习惯性的体育运动是否影响老年人I型和Ⅱ型T细胞因子的平衡。通过对9名老年妇女(平均年龄(63±1)岁，最大耗氧量(32.2±1.0)mL·kg-1·min-1)进行步行训练；挑选12名不进行运动训练的老年(妇女平均年龄(63±1)岁，最大耗氧量(27.8±0.9)mL·kg-1·min-1)和9名不进行运动训练的年轻妇女(平均年龄(26±1)岁，最大耗氧量(37.8±1.3)mL·kg-1·min-1)；然后检测了CD4+和CD8+T细胞中IFN-γ、IL-2和IL-4的水平，并对I型和Ⅱ型T细胞进行了比较。结果：老年人运动组表达IFN-γ的CD4+细胞数目与比青年非运动组比较，差异有显著性〖WT5”BX〗(P＜0.01)；老年运动组表达IL-2的CD8+的T细胞数目与老年非运动组比较差异有显著性P＜0.05)；青年组表达IL-4的CD8+细胞与老年非运动组比较，差异有显著性P＜0.01)；3组中CD4+和CD8+T细胞中IFN-γ/IL-4的比率差异无显著性。实验结果显示年龄对I型和Ⅱ型T细胞的影响比运动训练对它的影响更大。 关键词：运动；免疫；T淋巴细胞；最大耗氧量；老年人 中图分类号：G804.7 文献标识码：A 文章编号：1006-7116(2006)03-0054-04 |
HUANG La-xiu1， CHEN Xiao-wu2
| (1.Department of Physical Education； 2.Department of Anatomy of Medical School, Xianning Institute, Xianning 437100，China) Abstract: The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Methods Nine elderly women who train by walking (63±1)a,VO2max（32.2±1.0）mLkg-1·min-1),12age-matched untrained women (63±1)a,VO2max （27.8±0.9）mL·kg-1·min-1,and nine young untrained women(26±1)a, VO2max(37.8±1.3)mL·kg-1·min-1participated in the study. We measured interferon γ (IFN-γ),IL-2, and IL-4 in CD4+ and CD8+T cells, to compare type 1 and type 2 T cells. Results the number of CD4+ cells expressing intracellular IFN-γ(CD4+//IFN-γcell) significantly higher in the elderly trained than in the young (P＜0.01＝.The number of CD8+/IL-2 cells was significantly higher in the elderly trained than in the elderly untrained (P＜0.05＝.The number of cells was significantly higher in the young than in the elderly untrained (P＜0.01＝.No significant differences were apparent in the IFN-γ/IL-4 ratio within CD4+ and CD8+ cells from the three groups. Conclusion These results might indicate that the effect of age on the balance of type 1/type 2 T cells was stronger than the effect of physical training. Key words: exercise; immunity from disease; T-lymphocytes; VO2max; elderly |
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