| （肇庆学院 体育学系，广东 肇庆 526061） 摘要：使用跑台及低氧舱对SD大鼠进行了低氧、力竭实验，同时检测运动后即刻，1、2、4及7 d大鼠血清CK和骨骼肌XOD，以探讨低氧运动对其影响。结果发现：低氧、力竭运动后即刻、1 d及2 d大鼠血清CK明显升高，常氧运动组运动后4、7 d开始下降；低氧运动组运动后4 d时下降，而7 d时再次升高；低氧暴露7 d后血清CK达到最高值。低氧、力竭运动后即刻，1、2及4 d大鼠骨骼肌XOD明显升高，运动后7 d XOD开始下降；低氧暴露4 d后XOD达到最高值。提示：XOD的升高导致自由基生成增加，对骨骼肌产生损伤作用，可能使CK漏出，最终导致运动后血清CK升高。运动加低氧的双重刺激使大鼠氧化 应激作用加强，运动后骨骼肌修复延迟。 关键词：低氧；大鼠；力竭运动； 肌酸激酶； 黄嘌呤氧化酶 中图分类号：G804.7 文献标识码：A 文章编号： 1006-7116(2005)05-0043-03 |
YANG Hai-ping
| (Department of Physical Education, Zhaoqing Institute, Zhaoqing 526061,China) Abstract: The author carried out a hypoxic exhaust experiment on mice by using a treadmill and a hypoxic chamber, and measured the CK in serum and XOD in skeletal muscles of the mice immediately, on the 1st, 2nd, 4th, and 7th days, after the exercise, so as to study the effect of hypoxia exercise on the mice. The author revealed the following findings: The CK in serum of the mice showed a significant increase immediately, on the 1st and 2nd days, after hypoxic exhaust exercise, while that of the mice in normoxic exercise group began to decrease 4-7 days after the exercise; the CK in serum of the mice in hypoxic exhaust exercise group decreased 4 days after the exercise, yet it increased again on the 7th day; the CK in serum reached its maximum value 7 days after hypoxia exposure; the XOD in skeletal muscles of the mice showed a significant increase immediately, on the 1st 2nd and 4th days, after hypoxic exhaust exercise, and began to decrease 7 days after the exercise; the XOD reached its maximum value 7 days after hypoxia exposure. Hints: The rise of XOD would cause hyperplasia of free radicals, damage of skeletal muscles, and possibly CK leakage, eventually causing the rise of CK after exercise; doubled stimulations of exercise plus hypoxia would intensify oxidative reaction of mice, delaying the repair of skeletal muscles after exercise. Key words: hypoxia; mice; exhaust exercise; CK; XOD |
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