(1.华南师范大学 体育科学学院，广东 广州 510006；2.湖州师范学院 体育学院，浙江 湖州 313000) 摘 要：探讨有氧运动干预对抑郁症大鼠 HPA 轴激活状态的影响及其上游调控机制。以 WKY抑郁大鼠作为动物模型，进行 8 周有氧运动干预，以下丘脑 CRH 分泌情况反映 HPA 轴激活状态，通过海马 Glu 和 GABA 以及下丘脑中这两种神经递质受体表达探讨 HPA 轴激活的上游调控机制。结果发现：(1)抑郁大鼠 CRH 显著升高，表明其 HPA 轴过度激活，其机理应该与海马 Glu 和下丘脑 Glu 受体高表达、海马 GABA 和下丘脑 GABA 受体低表达直接相关。(2)运动干预可以显著降低 CRH 的分泌从而改善 HPA 轴的过度激活状态，其机理在于运动干预可下调海马 Glu 和下丘脑Glu 受体的表达，同时上调海马 GABA 和下丘脑 GABA 受体的表达。(3)运动干预可以取得与氟西汀干预相似的改善效应，表明有氧运动干预可以作为药物治疗抑郁症的良好替代手段。 |
LIU Wei 1 ，JIN Qian 2 ，HAO Xuan-ming 1
(1. School of Physical Education，South China Normal University，Guangzhou 510006，China；2. School of Physical Education，Huzhou University，Huzhou 313000，China) Abstract: This study aims to explore effect of aerobic exercise intervention on the activation degree of HPA axis in depressive rats and its upstream regulation mechanism. WKY depressive rats were used as animal models and to carry out 8-week aerobic exercise, and CRH secretion in hypothalamus were used to observe the activation degree of HPA axis, and through expression of Glu and GABA in hippocampus and their receptors in hypothalamus to observe upstream regulation mechanism activated by the HPA axis. The results suggested that: (1) CRH increased significantly in depressive rats, indicating that the HPA axis was over activated, and the mechanism should be directly related to the high expression of Glu in hippocampus and its receptor in hypothalamus, and the low expression of GABA in hippocampus and its receptor in hypothalamus. (2) Exercise intervention lowered HPA axis activation obviously so that the over activation degree of HPA axis could be improved, and the mechanism should be due to down-regulate the expression of Glu in hippocampus and its receptor in hypothalamus, and up-regulate GABA in hippocampus and its receptor in hypothalamus by exercise. (3) Exercise intervention could achieve improvement effect similar to fluoxetine intervention, which shows that aerobic exercise would be an advisable alternative means to replace the treatment of depression by drugs. |
下载本期全文：点击下载